皮肤损伤康复

肿瘤诊断与精准康复干预

生物治疗与组织再生康复

1997.09-2002.07 威廉希尔，临床医学，本科

2005.09-2007.07 威廉希尔，免疫学，硕士

2007.09-2010.06 威廉希尔，免疫学，博士

2002.07-2005.08 中山大学附属六院，住院医师

2010.09-2013.09 威廉希尔中日联谊医院，唐敖庆特聘教授实验室讲师

2013.09-2017.08 威廉希尔中日联谊医院胃肠外科，讲师

2014.03-2016.02 美国科罗拉多大学药学院，博士后

2017.08-2020.06 威廉希尔中日联谊医院胃肠外科，教授/博导

2018.06-2020.06 美国科罗拉多大学药学院，博士后

2020.08至今 威廉希尔中日联谊医院纳米医学转化研究中心，主任

1.《医院感染学》，威廉希尔出版社，编者：于丹，方琳，任平，池明，陈芳芳，宋佰慧，杨春艳，尚占斌，郑海筝，贾姣源，曹阳（2022）

2.《常用免疫学实验技术》（第2版），高等教育出版社，编者（2024）

3.《中国抗癌协会胃癌专业委员会发展历程回顾》，北京大学医学出版社，编委（2022）

1.基于纳米免疫的交叉学科实验创新教学改革，威廉希尔教学改革项目，主持

1.“即插即用”型肿瘤免疫多特异性抗体制备平台及其抗肿瘤机制的研究，院内项目—启明星计划—国际合作项目，2024.06-2027.05，30万，主持

2.基于天然抗肿瘤分子筛选鉴定一体化技术平台的有效成分精准发现及与细胞膜囊泡协同抗白血病机制研究，中国中医科学院科技创新工程项目，CI2023CO22YL，2024.02 -2027.02，参与

3.多价mRNA肿瘤疫苗的人工合成与应用研究，中国科学技术部，中国科技部重点研发项目，2024YFA0918600，2025.01-2028.12，160万，项目骨干

4.精准治疗白血病的仿生纳米氧化铁制备及仪器搭建，吉林省科技厅，20240305029YY，2024.01-2026.12，60万，在研，主持

5.中药复方及成分体内抗白血病活性及机制研究，中国中医科学院广安门医院（横向课题），2024.08.01-2025.08.01，15万，在研，主持

6.中药有效成分与纳米材料协同抗白血病机制研究，中国中医科学院广安门医院（横向课题），2024.08.01-2025.03.28，25万，在研，主持

7.靶向进入白血病细胞的仿生纳米氧化铁设计和制备，威廉希尔科技成果概念验证项目，000，2023.01-2024.12，200万，在研，主持

8.Ferumoxytol在急性髓系白血病中的治疗作用及免疫学机制研究，国家自然科学基金面上项目，32271446，2023.01-2026.12，54万，在研，主持

9.氢化合金靶向氢热-免疫联合治疗浅表实体瘤研究，吉林省卫生科研人才专项项目（拔尖人才），2022SCZ26，2022.11-2025.11，10万，在研，主持

10.铁基复合材料动态调节免疫微环境抑制肿瘤复发-可抑制骨与皮肤肿瘤术后复发的生物材料研制，科技部-国家重点研发计划，2021YFC2400603，2021.12-2024.11，135万，在研，项目骨干

11.肿瘤细胞膜载药靶向治疗白血病，吉林省卫生科研人才专项项目（领军人才），2020SCZ61，2020.07-2023.07，20万，结题，主持

12.纳米材料免疫应答与白血病靶向治疗，第四批国家“万人计划”青年拔尖人才，000，2019.07-2022.06，230万，结题，主持

13.纳米医学转化，威廉希尔高层次科技创新团队建设项目-威廉希尔中央高校基础研究基金，2019TD-36，2019.01-2024.12，300万，在研，主持

14.超顺磁氧化铁纳米材料用于肿瘤免疫治疗，吉林省发改委，2019C023，2019.01-2020.12，20万，结题，主持

15.补体C3介导的超顺磁氧化铁偶联CD33单抗载药纳米颗粒靶向治疗急性髓系白血病的实验性研究，国家自然科学基金面上项目，31771093，2018.01-2021.12，60万，结题，主持

1.Yuanyuan Li^#, Yike Xu^#, Wenwen Su^#, Jia Xu, Zifei Ye, Zhuoyi Wang, Qihui Liu^*,Fangfang Chen^*. Exploring the Immuno-Nano Nexus: A Paradigm Shift inTumor vaccines.Biomedicine & Pharmacotherapy.2025 Feb 7;184:117897.

2.Wei He^#,WenWu^#, Yuanyuan Li, Qihui Liu,PingRen,Siyu Shen, Jiandong Wu, Qiong Wu,Haiyan Liu^*,Fangfang Chen^*. Next generation nanoparticle protein corona characterization methods.Nanomedicine. 2025 Feb 6:1-3.

3.Wen Wu^#, Yuanyuan Li^#, Qihui Liu^#, Tao Liu, Yanan Zhao, Hui Shao, Ping Ren, Yueyang Tang, Jiayi Feng, Yihan Wang, Guodong Sun, Haiyan Liu^*, Yuansong Bai^*, andFangfang Chen^*.Dual-Targeted Drug Delivery to Myeloid Leukemia Cells viaComplement- and Transferrin-Based Protein Corona.Nano Lett.2025 Jan 8;25(1):147-156.

4.Yuanyuan Li^#, Wen Wu, Qihui Liu, Qiong Wu, Ping Ren, Xi Xi, Haiyan Liu, Jiarui Zhao, Wei Zhang, Zizhun Wang, Yuanyuan Lv, Bin Tian, Shuang Sun, Jiaqi Cui, Yangyang Zhao, Jingyuan Wu, Mingyuan Gao,Fangfang Chen^*. Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity.Nat Commun. 2024 Nov 29;15(1):10400.

5.Jiandong Wu^#, Dongxu Jiao^#, Qihui Liu^#, Bin Tian, Tao Liu, Qiong Wu, Yu Nan, Xin Chang, Shan Jiang, Qi Yang, Xiaoqiang Cui^*,Fangfang Chen^*.Atomicinterfaceengineering-mediatedmetallenenanozymeboostsefficientphotothermalcatalytictumor-specifictherapy.Adv Funct Mater.2024, 2408019.

6.Jiandong Wu^#,Qihui Liu^#, Dongxu Jiao^#, Bin Tian^#, Qiong Wu, Xin Chang, Hongyu Chu, Shan Jiang, Qi Yang, Tao Liu, Yue Zhang, Wei Zhang, Jinchang Fan, Xiaoqiang Cui^*,Fangfang Chen^*.Tensilestrain-mediatedbimetallenenanozyme forenhancedphotothermaltumorcatalytictherapy.Angew Chem Int Ed Engl.2024 Apr 9:e202403203.

7.Shuang Sun^#, Zhaocheng Xu^#, Ze Lin, Weiwei Chen, Yue Zhang, Mengjie Yan, Shengnan Ren, Qihui Liu, Huimin Zhu, Bin Tian, Jian Zhang, Weijia Zhang, Shan Jiang, Chuqiao Sheng, Jingyan Ge,Fangfang Chen^*, Zeyuan Dong^*. A biomimetic ion channel shortens the QT interval of type 2 long QT syndrome through efficient transmembrane transport of potassium ions.Acta Biomater.2024 May 3:S1742-7061(24)00229-0.

8.Lei Xing^#, Pinyi Ma^*,Fangfang Chen^*.A novel turn-on near-infrared fluorescent probe for highly sensitive in vitro and in vivo detection of acetylcholinesterase activity.Spectrochim Acta A Mol Biomol Spectrosc.2024 Apr 5;310:123954.

9.Yue Zhang^#, Shuang Sun, Yuanyu Wu,Fangfang Chen^*.Emerging Roles of Graphitic Carbon Nitride-based Materials in Biomedical Applications.ACS biomaterials science & engineering,202410(8), 4645–4661.

10.Yue Hu^#, Qing Nie, Xianling Cong, Wen Wu, Qiong Wu, Qihui Liu, Yuanyuan Li, Haiyan Liu, Jingyan Ge,Fangfang Chen^*. PEN-coated superparamagnetic iron-mediated delivery of siSnail2 to inhibit metastasis and promote ferroptosis in the treatment of cancer.Int J Pharm. 2024 Jan 25;650:123728.

11.Wen Wu^#, Qiong Wu, Qihui Liu, Yuanyuan Li, Ping Ren, Yuanyu Wu^*,Fangfang Chen^*,Identification and characterization of soft protein corona absorbed on iron oxide nanoparticles,Chinese J Anal Chem,2023, 51(5):100246.

12.Shengnan Ren^#, Dingquan Yang^#, Yongli Dong, Weidong Ni, Meiqi Wang, Lei Xing, Tong Liu, Wenjia Hou, Weixuan Sun, Haolong Zhang, Zhentao Yu, Yi Liu, Jingrui Cao, Hongbo Yan, Ye Feng, Xuedong Fang^*, Quan Wang^*,Fangfang Chen^*.Protamine 1 as a secreted colorectal cancer‐specific antigen facilitating G1/S phase transition under nutrient stress conditions.Cell Oncol (Dordr). 2023;46(2):357-373.

13.Xin Chang^#, Qiong Wu^#, Yuanyu Wu, Xi Xi, Jingrui Cao, Hongyu Chu, Qihui Liu, Yuanyuan Li, Wen Wu, Xuedong Fang^*,Fangfang Chen^*.Multifunctional Aumodified Ti3C2-MXene forphotothermal/enzymedynamic/immunesynergistictherapy,Nano Lett. 2022, 22(20): 8321-8330.

14.Weidong Ni^#, Wenhao Zhu, Wen Wu, Jie Chen^*, Ping Ren^*,Fangfang Chen^*.Nanoscale metal-organic framework-mediated immunogenic cell death boosting tumor immunotherapy,Mater Des, 2022, 222:111068.

15.Weidong Ni^#, Jiayan Wu, Huapan Fang, Yuanji Feng, Yingying Hu, Lin Lin, Jie Chen^*,Fangfang Chen^*,Huayu Tian^*. Photothermal-chemotherapy enhancing tumor immunotherapy by multifunctional metal-organic framework based drug deliverysystem,Nano Lett,2021,21(18):7796-7805.

16.Siyu Wang^#, Yue Song, Kunxia Cao, Lingxiao Zhang, Xuedong Fang,Fangfang Chen^*, Shouhua Feng, Fei Yan^*.Photothermaltherapymediated bygoldnanocagescomposed ofanti-PDL1 andgalunisertib forimprovedsynergisticimmunotherapy incolorectalcancer,Acta Biomater, 2021,134:621-632.

17.Weidong Ni^#,Jiayan Wu,Yuanji Feng,Yingying Hu,Haiyan Liu,Jie Chen^*,Fangfang Chen^*,Huayu Tian^*.Metformin reprograms tumor microenvironment and boosts chemoimmunotherapy in colorectal cancer.Biomater Sci. 2022;10(19):5596-5607.

18.Qiong Wu^#, Wen Wu ,Fangfang Chen, Ping Ren^*.Highly sensitive and selective surface plasmonresonance biosensor for the detection ofSARS-CoV-2 spike S1 protein,Analyst, 2022, 147(12), 2809-2818.

19.Jingrui Cao#, Qiong Wu, Xin Chang, Hongyu Chu, Hong Zhang*, Xuedong Fang*,Fangfang Chen,Ratiometric detection and imaging of endogenous alkaline phosphatase activity by fluorescein-coumarin-based fluorescence probe,Spectrochim Acta A Mol Biomol Spectrosc. 2022;281:121615.

20.Wen Wu^#, Qiong Wu, Shengnan Ren, Zhuo Liu^*,Fangfang Chen^*,Ti3C2-MXene-assisted signal amplification for sensitive and selective surface plasmon resonance biosensing of biomarker,Chinese J Anal Chem,2022, 50(2):13-18.

21.Yunhan Zhang^#, Meihui Xia^#, Zizhen Zhou, Xiaoqing Hu, Jiabin Wang, Meiyu Zhang, Yi Li, Liankun Sun,Fangfang Chen^*, Huimei Yu^*.p53 promoted ferroptosis in ovarian cancer cells treated with human serum incubated-superparamagnetic iron oxides.Int J Nanomedicine. 2021, 16:283-296.

22.Yue Hu^#, Qing Nie, Mingrui Dai,Fangfang Chen^*, Hui Wu^*,Histone deacetylases inhibit the Snail2-mediated EMT during metastasis of hepatocellular carcinoma cells.Front Cell Dev Biol.2020, 8: 752.

23.Chunyan Yang^#,Fangfang Chen^#*, Ping Ren, Laren Lofchy, Chun Wan, Jingshi Shen, Guankui Wang, Hanmant Gaikwad, Jessica Ponder, Craig T. Jordan, Robert Scheinman, Dmitri Simberg^*. Delivery of a model lipophilic membrane cargo to bone marrow via cell-derived microparticles.J Control Release. 2020, 326(2020), 324-334.

24.Siyu Wang^#, Fei Yan, Ping Ren, Yi Li, Qiong Wu, Xuedong Fang,Fangfang Chen^*, Ce Wang^*. Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application.Int J Biol Macromol. 2020;158, 9-17.

25.Jieman Hu^#, Yuanyu Wu, Fujian Ji, Xuedong Fang^*,Fangfang Chen^*. Peer support as an ideal solution for racial/ethnic disparities in colorectal cancer screening: evidence from a systematic review and meta-analysis.Dis Colon Rectum. 2020, 63(6): 850-858.

26.Yi Liu^#, Jingtong Zhao, Jinlan Jiang,Fangfang Chen^*, Xuedong Fang^*. Doxorubicin delivered using nanoparticles camouflaged with mesenchymal stem cell membranes to treat colon cancer.Int J Nanomedicine. 2020, 15:2873-2884.

27.PingRen^#,ChunyanYang, Laren A. Lofchy, Guankui Wang,Fangfang Chen^*, Dimitri Smiberg^*. Establishing in situ closed circuit perfusion of lower abdominal organs and hind limbs in mice.J Vis Exp.2020, (162):10.3791/60847.

28.Qiong Wu^#, Ningbo Li, Ying Wang, Yanchao Xu, Jiandong Wu, Guangri Jia, Fujian Ji, Xuedong Fang*,Fangfang Chen^*, Xiaoqiang Cui^*.Ultrasensitive and selective determination of carcinoembryonic antigen using multifunctional ultrathin amino-functionalized Ti3C2-MXene nanosheets.Anal Chem. 2020,92(4): 3354-3360.

29.Qiong Wu^#, Ningbo Li, Ying Wang, Ying Liu, Yanchao Xu, Shuting Wei, Jiandong Wu, Guangri Jia, Xuedong Fang,Fangfang Chen^*,Xiaoqiang Cui^*. A 2D transition metal carbide MXene-based SPR biosensor for ultrasensitive carcinoembryonic antigen detection.Biosens Bioelectron. 2019, 144, 111697.

30.Ze Zhang^#, Shouqian Wang, Yahui Liu^*, Zihui Meng,Fangfang Chen^*. Low lncRNA ZNF385D‐AS2 expression and its prognostic significance in liver cancer.Oncol Rep. 2019, 42(3): 1110-1124.

31.Ze Zhang^#, Xinyue Deng, Yuanda Liu, Yahui Liu^*, Liankun Sun^*,Fangfang Chen^*. PKM2, function and expression and regulation and regulation.Cell Biosci. 2019, 9: 52.

32.Fangfang Chen^#, Qiong Wu^#, Daqian Song, Xinghua Wang, Pinyi Ma, Ying Sun^*.Fe3O4@PDA immune probe-based signal amplification in surface plasmon resonance (SPR) biosensing of human cardiac troponin I.Colloids Surf B Biointerfaces. 2019, 177:105-111.

33.Vivian P. Vu^#, Geoffrey B. Gifford,Fangfang Chen, Halli Benasutti, Guankui Wang, Ernest V. Groman, Robert Scheinman, Laura Saba, Seyed Moein Moghimi, Dmitri Simberg^*. Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles.Nat Nanotechnol. 2019, 14(3): 260-268.

34.Fujian Ji^#, Yuanyu Wu, Zhe An, Xuesong Liu, Junnan Jiang,Fangfang Chen^*,Xuedong Fang^*.Expression of both poly r(C) bindingprotein 1 (PCBP1) and miRNA-3978is suppressed in peritoneal gastriccancer metastasis.Sci Rep.2017, 7(1):15488.

35.Fangfang Chen^#, Guankui Wang^#, James I. Griffin,Barbara Brenneman, Nirmal K. Banda, V. Michael Holers, Donald S. Backos, LinPing Wu, Seyed Moein Moghimi and Dmitri Simberg^*. Complement proteins bind to nanoparticle proteincorona and undergo dynamic exchange in vivo.Nat Nanotechnol.2017,12(4):387-393.

1.一种诊断胃癌的PCR试剂盒，专利号：ZL 2020 1 1266754.3，授权号：CN 112159850 B，授权时间：2021年8月24日

2.SCTAG在制备诊断胃癌的试剂盒的应用，专利号：ZL 2020 1 1268995.1，授权号：CN 112345757 B，授权时间：2021年10月22日

1.长春市三八红旗手（2024.03）

2.全国第二届博士后创新创业大赛银奖（2023.10.28）

3.威廉希尔白求恩第三医院仁心人才（2023.04.26）

4.中国一汽红旗教师-优秀奖（2022.09）

5.第十七届中国青年女科学家奖（2022.07）

6.吉林省第八批拔尖创新人才称号/第三层次（20221083216，2022.01.13）

7.第十六届吉林省青年科技奖（2021.09.23）

8.吉林省自然科学学术成果奖一等奖/论文类（20171015，2018.05）

获奖项目：超顺磁铁纳米材料与血清蛋白结合模式（1/9）

9.2016年威廉希尔优秀博士后

1.中国抗癌协会第五届胃癌专业委员会基础与病理学组委员

2.“全国博士后国际交流计划”博士后联谊会理事长

3.中国病理生理学会第九届免疫专业委员会委员

4.中国抗癌协会第四届纳米肿瘤学专业委员会委员

5.吉林省检测技术学会理事

6.中国抗癌协会第七届胃癌专业委员会委员

7.长春市医学会第十二届理事会转化医学专科委员会副主任委员